Demon in the Freezer Overview

The Demon in the Freezer is a 2002 non-fiction book on the biological weapon agents smallpox and anthrax and how the American government develops defensive measures against them. It was written by journalist Richard Preston, also author of the best-selling book The Hot Z matchless (1994), about outbreaks of Ebola virus in Africa and Reston, Virginia and the US governments response to them. The book is primarily an account of the Smallpox Eradication Program (196780), the ongoing perception by the U. S. overnment that smallpox is still a potential biological terrorism agent, and the controversy over whether or not the remaining samples of smallpox virus in Atlanta and Moscow (the demon in the freezer) should be finally destroyed. However, the generator was overtaken by events the 9/11 attacks and the anthrax letter incidents (called Amerithrax), both in 2001 and so much of the book interweaves the anthrax investigation with the smallpox material in an awkward 1 and somewhat disjoin ted 23 manner. persona 1, Something in the Air, begins h a day-by-day account of the anthrax letter attacks in Florida and Washington, DC, for the period 2 to 15 October 2001. Robert Stevens, a photo retoucher for the tabloid, The Sun was a victim and US Senator Tom Daschle was an intended victim. The reactions of the FBI, the CDC and the U. S. Army Medical Research Institute of Infectious Diseases (USAMRIID) atomic number 18 detailed. slit 2, The daydream Demon, looks back to an outbreak of smallpox at St Walberga Hospital in Meschede, Germany.The successful efforts organized by local public health authorities and the WHO including a textbook example of ring vaccination containment are described. Section 3, To Bhola Island, describes the variety and evolution of poxviruses and the history of smallpox in particular. The story of the SEP (Smallpox Eradication Program, referred to passim as the Eradication), led by DA Henderson and others is recounted.The more personal story of physician, counterculture figure, and future virtual community pioneer Lawrence Brilliant is told as his Indian guru, Neem Karoli Baba exhorts him in 1970 to join the SEP and go eradicate smallpox. (Brilliant ended up fighting the outbreak at the Tatanagar Railway Station in Bihar. Finally, the Maximum Containment Facility (MCF) of the CDC in Atlanta is described. Section 4, The Other Side of the Moon, begins with an account of the 1989 defection to the UK of Vladimir Pasechnik, the first Soviet bioweaponeer to flee to the West.Pasechnik described Biopreparat, the Soviet biological weapons program, to MI6, including their genetically modified, antibiotic resistant anthrax and their smallpox program at the site known as Vector. The fact that the Russians had armed ICBMs with both set upon and smallpox is revealed. Various biological weapon facilities in Russia and Iraq are described. Finally, the history and work of the Ad Hoc Committee on Orthopox Infections is related. This group of the WHO has hotly debated since 1980 over the slew of the remaining samples of smallpox in the last two official repositories.DA Henderson has been in favor of destruction, while US Army scientist Peter Jahrling has been against it on the basis that pass on research is needed since smallpox almost certainly exists (he believes) outside of the repositories. Section 5, A Woman with a Peaceful Life, tells the story of USAMRIID microbiologist and epidemiologist Dr Lisa E. Hensley who was originally recruited to do Ebola work. A January 2000 accident in the AA4 Hot Suite that Hensley experienced, along with the protocols that followed it, is described.The efforts of USAMRIID scientists to get approval to do smallpox research on animals is described including the FDAs sensual Efficacy Rule and the WHO General Assemblys provisional permission to do research for three years (19992002). A Monkey Cabinet is intentional at USAMRIID and CDC for use in the possible investigation of the qu estion of whether animals can be infected with smallpox. The development of a lethal, genetically engineered mousepox virus (the Jackson-Ramshaw virus) and its implications for bioterrorism are described.Finally, the awakening of the smallpox at the CDCs MCF West in 2001 by US Army investigators to induce smallpox disease in monkeys for the first clipping is dramatically recounted. Section 6, The Demons Eyes, continues the story of the induction of smallpox disease in monkeys at the CDC in 2001. It was determined that the Harper touch of smallpox kills monkeys slowly while the India strain kills them quickly. This was the first time that smallpox had ever been shown capable of infecting non-humans. Of eight monkeys infected, seven diedsix of hemorrhagic smallpox and one of the classic pustular type.There follows a discussion of the need and justification for animal-use smallpox experiments. The emergency evacuation of the Army workers in the MCF West on 9/11 is described. Section 7, The Anthrax Skulls, relates the atmosphere at the Department of wellness and Human Services and their actions at the time of the 9/11 attacks. The story of the Amerithrax investigations is picked up again in day-by-day detail for the period 16 to 25 October 2001. The response by the FBI, HHS, DOJ, CIA and the White House are detailed. Actions at USAMRIID and USAMRMC are also described. USAMRIID became the FBIs reference laboratory for forensic evidence related to the bioterror incident. ) The events leading to Dr Steven Hatfill becoming a DOJ person of interest are related. Finally, the indignation of Alfred Sommer, dean of the Johns Hopkins School of Public Health at the news of the Army animal smallpox experiments is described as well as a reiteration of DA Hendersons opposition to the same. Section 8, Superpox, the last section, begins with a description of an attempt at replication of the Jackson-Ramshaw virus at a lab at the Saint Louis University School of Medicine by Mark Buller working for USAMRIID.The potential for a similarly engineered super-smallpox virus for use by a terrorist is examined. The procedure for the transfection of an interleukin-4 gene into a mousepox virus is described. Finally, an unusual artefact the preserved arm of a 3 or 4 year old child with classic smallpox lesions, discovered in 1999 and now housed at USAMRIIDis described. This leads the author to muse that the dream of the total eradication had failed, because although we could eradicate smallpox from nature, we could not uproot the virus from the human heart.